IN-VITRO ANTIMYCOPLASMAL ACTIVITIES OF RUFLOXACIN AND ITS METABOLITE MF-922

The in vitro activities of rufloxacin and its metabolite, MF 922, were compared with those of ofloxacin, ciprofloxacin, erythromycin, and mi nocycline against Mycoplasma pneumoniae, Mycoplasma hominis, Mycoplasm a fermentans, and urealyticum urealyticum. Rufloxacin, MF 922, and cip rofloxacin shared similar activities against all mycoplasmas tested. ( MICs for 90% of isolates tested [MIC(90)s], 0.5 to 4 mu g/ml). Ofloxac in had the lowest MIC(90)s for U. urealyticum, M. fermentans, and M. h ominis (MIC(90)s, 0.25 to 1 mu g/ml) and erythromycin had the lowest M IC(90) for M. pneumoniae (MIC(90), 0.004 mu g/ml).