COMPETITIVE-BINDING ANALYSIS OF MONOCLONAL-ANTIBODIES REACTIVE WITH PORCINE ALVEOLAR MACROPHAGES USING ANTI-CD14 AND ANTI-CD18

Authors
KIELIAN T MCVEY DS DAVIS WC KIM YB BLECHA F
Citation
T. Kielian et al., COMPETITIVE-BINDING ANALYSIS OF MONOCLONAL-ANTIBODIES REACTIVE WITH PORCINE ALVEOLAR MACROPHAGES USING ANTI-CD14 AND ANTI-CD18, Veterinary immunology and immunopathology, 43(1-3), 1994, pp. 273-278
Citations number
11
Categorie Soggetti
Immunology,"Veterinary Sciences
Journal title
Veterinary immunology and immunopathology → ACNP
ISSN journal
01652427
Volume
43
Issue
1-3
Year of publication
1994
Pages
273 - 278
Database
ISI
SICI code
0165-2427(1994)43:1-3<273:CAOMRW>2.0.ZU;2-5
Abstract
Four monoclonal antibodies (mAb) from the myeloid subset panel of the First International Swine CD Workshop (74-22-15, DH59B, PM16-6, and MU C21A) were analyzed using competitive inhibition studies with anti-hum an CD14 (My4) and anti-human/anti-porcine CD18 (MHM23) on porcine alve olar macrophages. Results suggested that none of the mAb tested recogn ized CD14 or CD18 on porcine alveolar macrophages. Additionally, the c ross-reactivity of My4 with porcine alveolar macrophages was establish ed.