Kr. Jerome et al., A SURVIVOR OF BREAST-CANCER WITH IMMUNITY TO MUC-1 MUCIN, AND LACTATIONAL MASTITIS, Cancer immunology and immunotherapy, 43(6), 1997, pp. 355-360
The human mucin, MUC-1, is a transmembrane glycoprotein that is produc
ed by both normal an malignant epithelium. The MUC-1 produced by malig
nant epithelium is underglycosylated, which leads to the expression by
tumors of novel T and B cell epitopes on the mucin polypeptide core.
Similar underglycosylation occurs in the lactating breast. In this rep
ort, we describe a long-term survivor of breast cancer whose tumor str
ongly expressed the T- and B-cell-stimulatory epitopes. Five years aft
er presenting with the tumor, the patient had her first pregnancy, at
which time she developed fulminant lymphocytic mastitis. We demonstrat
e that the lactating breast produced mucin expressing the same ''tumor
-specific'' epitopes as the original cancer. The patient had circulati
ng anti-mucin antibodies of both the IgM and IgG isotypes (these areno
t found in normal controls), and mucin-specific cytotoxic T lymphocyte
s in the peripheral blood. Limiting - dilution analysis for mucin - sp
ecific cytotoxic T lymphocytes in three different experiments yielded
frequencies of 1 in 3086, 1 in 673, and 1 in 583, compared to approxim
ately 1 in 10(6) in normal controls. The patient remains clinically fr
ee of carcinoma after 5 additional years of follow-up. We propose that
the original tumor primed the patient's immune response against the m
ucin epitopes, and that the reexpression of these epitopes on the lact
ating breast evoked a secondary immune response. It is tempting to spe
culate that the vigor of her anti-mucin immunity may have helped prote
ct this patient against recurrent tumor.