LIPID-HORMONAL INTERRELATIONS IN YOUNG ME N WITH A HISTORY OF MYOCARDIAL-INFARCTION (MATERIALS OF THE FAMILY REGISTERS IN NOVOSIBIRSK AND BISHKEK)

Altogether 226 male probands who suffered large-focal or transmural my ocardial infarction (MI) before reaching 50 years were examined in Nov osibirsk and Bishkek in one stage according to the unified program. In Novosibirsk all the probands were Russians whereas in Bishkek 75 prob ands were Kirghizs and 71 were Russians. The probands were examined wi thin a period of 1 to 3 years after MI. The lipid and lipoprotein plas ma content was determined by standardized methods on a Teknikon AAP au toanalyzer. The content of thyroid hormones, insulin and cortisol was measured by means of RIA-kits and that of apolipoprotein B (ApoB) by r adial immunodiffusion. It turned out that the patients from Novosibirs k demonstrated the highest content of cholesterol, low density lipopro tein cholesterol, the highest index of atherogenicity, the highest con centration of ApoB, and hyperinsulineamia. In the probands of both nat ionalities from Bishkek, the lipid spectrum did not differ substantial ly from the populational norm, the content of ApoB in the Russian prob ands was slightly lower than in those from Novosibirsk whereas in Kirg hizs, the least content of thyroxin was recorded.