REGRESSION OF STRUCTURAL AND FUNCTIONAL A LTERATIONS IN THE HYPERTROPHIC LEFT-VENTRICLE AS A RESULT OF A LONG-TERM CORRECTION OF ARTERIAL-PRESSURE WITH INGIBEIS (CHILASAPRIL)

The regression of structural and functional alteration in the hypertro phic left ventricle was measured in the course of long-term correction of arterial pressure with a new inhibitor of angiotensin-converting e nzyme ingibeis (chilasapril) in 23 patients with essential hypertensio n stage II-III. The results were for the most part obtained at echocar diography providing basic hemodynamic parameters and those of left ven tricular diastolic function. Adaptability of the hypertrophic myocardi um in response to physical loading was studied dynamically under isome tric exercise test. The findings proved high efficacy of chilasapril i n monotherapy of arterial hypertension. Long-term (6 months) therapy o f left ventricular hypertrophy provides regression of the latter and i mproves left ventricular diastolic function, pumping capacity. In the course of arterial hypertension correction relevant patients with asso ciated coronary heart disease improved their condition, demonstrated l ess frequent ECG changes indicative of ischemia.