JUVENILE GLAUCOMA LINKED TO THE GLC1A GENE ON CHROMOSOME 1Q IN A PANAMANIAN FAMILY

PURPOSE: To characterize clinically and genetically autosomal dominant juvenile-onset primary open-angle glaucoma in a Panamanian family, ME THODS: Twenty members of a six-generation family underwent ophthahmolo gic examination and genetic screening with markers near the GLC1A gene on chromosome 1q. RESULTS: Linkage analysis disclosed evidence linkin g primary open angle glaucoma in this family to the GLC1A gene on chro mosome 1q, with a maximum lod score of 3.75 for marker D1S431 at an es timated recombination fraction of 0.00, CONCLUSIONS: This is the first report of a Panamanian family in which primary open-angle glaucoma is linked to the GLC1A gene on chromosome 1q.