TAXOL CHEMISTRY - 7-O-TRIFLATES AS PRECURSORS TO OLEFINS AND CYCLOPROPANES

Authors
JOHNSON RA NIDY EG DOBROWOLSKI PJ GEBHARD I QUALLS SJ WICNIENSKI NA KELLY RC
Citation
Ra. Johnson et al., TAXOL CHEMISTRY - 7-O-TRIFLATES AS PRECURSORS TO OLEFINS AND CYCLOPROPANES, Tetrahedron letters, 35(43), 1994, pp. 7893-7896
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
43
Year of publication
1994
Pages
7893 - 7896
Database
ISI
SICI code
0040-4039(1994)35:43<7893:TC-7AP>2.0.ZU;2-K
Abstract
7-O-Triflates of baccatin III or of taxol analogs are convenient precu rsors in alternate syntheses of Delta(6,7)-taxols and 7 beta,8 beta-me thano (cyclopropyl) taxols, two of the products initially obtained fro m reaction of taxols with methylDAST; hydrazine is an effective reagen t for conversion of the 10-acetate group to the hydroxyl group.