ENANTIOMER SEPARATION OF 2-ARYLPROPIONIC ACIDS ON AN ERGOT ALKALOID-BASED STATIONARY-PHASE MICROBORE COLUMN APPLICATION

The separation of enantiomers of underivatized ketoprofen, as well as a number of other non-steroidal anti-inflammatory drugs, was studied b y high performance liquid chromatography using a recently developed ch iral stationary phase packed in a microbore column. Electrostatic and pi-pi interactions are assumed to control the retention of the analyte s. The enantioselectivity remains constant in a wide range of organic modifier concentration, and is restricted to a pH window ranging from 2.5 to 5.0.