Jx. Sun et al., PHARMACOKINETIC INTERACTION STUDY BETWEEN BENAZEPRIL AND AMLODIPINE IN HEALTHY-SUBJECTS, European Journal of Clinical Pharmacology, 47(3), 1994, pp. 285-289
Pharmacokinetic interaction between benazepril (ACE inhibitor) and aml
odipine (calcium channel blocker) was studied in 12 healthy subjects.
Single doses of benazepril hydrochloride (10-mg tablet) and amlodipine
besylate (tablet equivalent to 5 mg amlodipine) were administered alo
ne or in combination according to a three-way, Latin-Square, randomize
d crossover design. Serial blood samples were collected following each
administration for the determination of benazepril and its active met
abolite benazeprilat and amlodipine. The mean values of AUC (0-4 h), C
-max and T-max for benazepril given as combination versus given alone
were 161 vs 140 ng.h.ml(-1), 168 vs 149 ng.ml(-1), and 0.5 vs 0.6 h. T
he mean values of AUC (0-24 h), C-max and T-max for benazeprilat after
benazepril given as combination Versus given alone were 1470 vs 1410
ng.h.ml(-1), 292 vs 257 ng.ml(-1), and 1.7 vs 1.5 h. The mean values o
f AUC (0-144 h), C-max and T-max for amlodipine given as combination v
ersus given alone were 118 vs 114 ng.h.ml(-1), 2.5 vs 2.3 ng.ml(-1), a
nd 8.3 vs 9.0 h. The differences in these pharmacokinetic pa rameters
between the combination and monotherapy treatments were not statistica
lly significant based on ANOVA. The results of this study indicate tha
t no pharmacokinetic interaction existed between the two drugs.