The endoscopic Congo red-methylene blue tested was performed on 51 tum
ors of the large intestine. Results revealed that colorectal adenocarc
inomas and adenomas bleached the Congo red and methylene blue sprayed
over their surface and so appeared in sharp contrast to the bluish red
mucosa of unaffected areas. No bleaching of the dyes was observed on
the surface of non-neoplastic polyps. Moderately differentiated adenoc
arcinomas, submucosal or advanced cancers, and adenomas with severe at
ypia bleached the dyes most frequently. Thus this test facilitates ear
ly detection of colorectal tumors.