PHOSPHATIDYLSERINE SUPPRESSES MYELIN-INDUCED EXPERIMENTAL ALLERGIC NEURITIS (EAN) IN LEWIS RATS

Authors
MAEDA Y MAEDA R PRINEAS JW LEDEEN RW
Citation
Y. Maeda et al., PHOSPHATIDYLSERINE SUPPRESSES MYELIN-INDUCED EXPERIMENTAL ALLERGIC NEURITIS (EAN) IN LEWIS RATS, Journal of neuropathology and experimental neurology, 53(6), 1994, pp. 672-677
Citations number
36
Categorie Soggetti
Pathology,Neurosciences,"Clinical Neurology
Journal title
Journal of neuropathology and experimental neurology → ACNP
ISSN journal
00223069
Volume
53
Issue
6
Year of publication
1994
Pages
672 - 677
Database
ISI
SICI code
0022-3069(1994)53:6<672:PSMEAN>2.0.ZU;2-0
Abstract
Phosphatidylserine administered as an aqueous dispersion to myelin-ind uced experimental allergic neuritis rats had a significant effect on d isease course. Intraperitoneal injections of 30 mg/kg were given daily beginning at the onset of disease and continued for 14 days. Clinical severity and mortality were markedly reduced by this treatment as com pared to saline controls. Improved clinical outcome was associated wit h a reduction in peripheral nerve pathology. A possible mechanism invo lving tumor necrosis factor is discussed.