COEXISTENT CUTANEOUS T-CELL LYMPHOMA AND B-CELL MALIGNANCY

Background: The coexistence of cutaneous T-cell lymphoma (CTCL) and a B-cell malignancy (BCM) is rare. Objective: Our aim was to assess the clinical and pathologic aspects of coexistent CTCL and BCM and to exam ine potential explanations for this association. Methods: We report si x cases of concurrent CTCL and BCM in which B- and T-cell lineages wer e demonstrated by immunologic studies. The literature includes 13 addi tional cases. All 19 CTCL-BCM cases are reviewed. Results: CTCL either preceded or followed the BCM, which was a low-grade malignancy in mos t cases (16 of 19). Possible explanations for the association include a genetic predisposition, underlying viral infection, chemotherapy-ind uced carcinogenesis, stimulation of a B-cell clone by malignant helper T cells, and alterations in progenitor cells before determination of B- and T-cell lineage. Conclusion: An alteration in progenitor cells, with subsequent oncogenic activation of variable origin, might account for most cases of coexistent CTCL and BCM.