Men who are more active live longer, but it is not clear if the same i
s true for women. We monitored 1404 women aged 50 to 74 who were free
of cardiovascular disease. We assessed physical activity levels and ra
nked subjects into quartiles. After 16 years, 319 (23%) women had died
. The relative risk of mortality, compared to the least active quartil
e, was as follows: second quartile, 0.95 (95% confidence interval [C]0
.72 to 1.26); third quartile, 0.63 (95% CI 0.46 to 0.86); most active
quartile, 0.67 (95% Cl 0.48 to 0.92). The relative risks were not chan
ged by adjustment for cardiac risk factors, chronic obstructive pulmon
ary disease, or cancer or by excluding all subjects who died in the fi
rst 6 years (to eliminate occult disease at baseline). There was no as
sociation between activity levels and cardiovascular morbidity or mort
ality. We conclude that women who were more active lived longer; this
effect was not the result of decreased cardiovascular disease.