HYPERPROINSULINEMIA IN JAPAN

Authors
KANAZAWA Y KUZUYA N TAKEUCHI Y KUBO F YAMAMOTO W NODA M
Citation
Y. Kanazawa et al., HYPERPROINSULINEMIA IN JAPAN, Diabetes research and clinical practice, 24, 1994, pp. 190000143-190000144
Citations number
10
Categorie Soggetti
Gastroenterology & Hepatology","Endocrynology & Metabolism
Journal title
Diabetes research and clinical practice → ACNP
ISSN journal
01688227
Volume
24
Year of publication
1994
Supplement
S
Pages
190000143 - 190000144
Database
ISI
SICI code
0168-8227(1994)24:<190000143:HIJ>2.0.ZU;2-Z
Abstract
Four families with hyperproinsulinemia found in Japan were described. The details of the first case, who was investigated by Kanazawa et al. , were reported and the similarity of the first case to the following cases was shown. Arginine 65 of the proinsulin molecule might be a hot spot of the insulin gene. A possible abnormality of insulin release i n affected individuals was disclosed by investigation of the family me mbers of the first case.