[H-3] L-694,247 LABELS THE 5-HT1D-BETA RECEPTOR IN PIG CAUDATE MEMBRANES

This study, carried out in pig caudate membranes, characterises the ra dioligand binding site labelled with [H-3]L-694,247 -1,2,4-oxadiazol-5 -yl]-1H-indole-3-yl]ethylamine). The affinities of 27 standard compoun ds are consistent with binding to a 5-HT1D recognition site. In additi on the results indicate that, under the assay conditions described, [H -3]L-694,247 specifically labels the 5-HT1D beta recognition site sinc e ketanserin and ritanserin display a low affinity consistent with the ir activities at this subtype of the 5-HT1D receptor.