USE OF MICROCALORIMETRY IN THE FIELD OF PHARMACEUTICAL SCIENCES .1. MEASUREMENT OF DRUG DISSOLUTION FROM SOLID DOSAGE FORMS

A microcalorimetric method for measurement of the dissolution rate of sodium chloride was presented. The method applied the deconvolution th eory to heat conduction microcalorimetry. When a calorimetric curve fo r the heat of dilution was regarded as the response for a unit impulse input (heat conduction profile), a calorimetric curve for the heat of solution was considered to be the convolution of dissolution profile and heat conduction profile. Thus, the dissolution profile was calcula ted from the calorimetric curves for the heat of dilution and for the heat of solution by a numerical deconvolution. Dissolution rate determ ined by the calorimetric method coincided web with that obtained by a titration method.