SYNTHESIS OF A FLUORINATED ANALOG OF 1-AMINOCYCLOPROPANE CARBOXYLIC-ACID

Authors
SLOAN MJ KIRK KL
Citation
Mj. Sloan et Kl. Kirk, SYNTHESIS OF A FLUORINATED ANALOG OF 1-AMINOCYCLOPROPANE CARBOXYLIC-ACID, Tetrahedron letters, 38(10), 1997, pp. 1677-1680
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
10
Year of publication
1997
Pages
1677 - 1680
Database
ISI
SICI code
0040-4039(1997)38:10<1677:SOAFAO>2.0.ZU;2-C
Abstract
A convenient synthesis of 2-fluoro-1-aminocyclopropane-1-carboxylic ac id is described. Cyclopropanation of ethyl 2-(3,4-dimethoxyphenyl)-3-f luoroacrylate followed by Curtius rearrangement, oxidative cleavage of the aromatic ring, and deprotection, produced the alpha-amino acid.