AN ACETAL DERIVATIVE OF ILLUDIN-S WITH IMPROVED ANTITUMOR-ACTIVITY

Authors
MCMORRIS TC YU JA GANTZEL PK ESTES LA KELNER MJ
Citation
Tc. Mcmorris et al., AN ACETAL DERIVATIVE OF ILLUDIN-S WITH IMPROVED ANTITUMOR-ACTIVITY, Tetrahedron letters, 38(10), 1997, pp. 1697-1698
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
10
Year of publication
1997
Pages
1697 - 1698
Database
ISI
SICI code
0040-4039(1997)38:10<1697:AADOIW>2.0.ZU;2-4
Abstract
Methylene acetal of an epimer of illudin S (5) was obtained by treatin g illudin S with a large excess of paraformaldehyde in 1N H2SO4 soluti on. X-ray crystallographic analysis showed that the configuration at t he allylic carbon has been inverted. This acetal was found to be less toxic and showed a higher therapeutic index than illudin S. (C) 1997 E lsevier Science Ltd.