NEW MULTI-COUPLING BENZYLIC ZINC REAGENTS FOR THE PREPARATION OF FLEXIBLE AROMATIC-COMPOUNDS

Authors
ROTTLANDER M KNOCHEL P
Citation
M. Rottlander et P. Knochel, NEW MULTI-COUPLING BENZYLIC ZINC REAGENTS FOR THE PREPARATION OF FLEXIBLE AROMATIC-COMPOUNDS, Tetrahedron letters, 38(10), 1997, pp. 1749-1752
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
10
Year of publication
1997
Pages
1749 - 1752
Database
ISI
SICI code
0040-4039(1997)38:10<1749:NMBZRF>2.0.ZU;2-F
Abstract
The benzylic zinc reagents 3a-c bearing a triflate group in o-, m- or p-position are new efficient multi-coupling reagents reacting stepwise with an aryl iodide (Ar-1-I) and an arylzinc bromide ((ArZnBr)-Zn-2) in the presence of the appropriate palladium catalyst and the suitable phosphine ligand leading to polyfunctional flexible aromatic products of type 5. This methodology is appropriate for applications in combin atorial chemistry. (C) 1997 Elsevier Science Ltd.