ISOLATION AND SYNTHESIS OF THE FIRST NATURAL 6-HYDROXIMINO 4-EN-3-ONESTEROIDS FROM THE SPONGES CINACHYRELLA SPP

Authors
RODRIGUEZ J NUNEZ L PEIXINHO S JIMENEZ C
Citation
J. Rodriguez et al., ISOLATION AND SYNTHESIS OF THE FIRST NATURAL 6-HYDROXIMINO 4-EN-3-ONESTEROIDS FROM THE SPONGES CINACHYRELLA SPP, Tetrahedron letters, 38(10), 1997, pp. 1833-1836
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
10
Year of publication
1997
Pages
1833 - 1836
Database
ISI
SICI code
0040-4039(1997)38:10<1833:IASOTF>2.0.ZU;2-4
Abstract
Two new 6-hydroximino-4en-3-one steroids: (24R, 6E)-24-ethylcholest-6- hydroximino-4-en-3-one (1) and (6E) cholest-6-hydroximino-4-en-3-one ( 2), accompanied by the known cholest-4-en-3-one were isolated from a m ixture of two morphospecies of the sponge Cinachyrella (C. alloclada a nd C. apion). Use of spectroscopic methods (NMR and MS) was key to est ablish their structures which were confirmed by synthesis. Described i n this report are the fast hydroximino steroids derived from a natural source. (C) 1997 Elsevier Science Ltd.