Rja. Jebbink et al., HYPERGLYCEMIA INDUCES ABNORMALITIES OF GASTRIC MYOELECTRICAL ACTIVITYIN PATIENTS WITH TYPE-I DIABETES-MELLITUS, Gastroenterology, 107(5), 1994, pp. 1390-1397
Background/Aims: Blood glucose concentration has been shown to be an i
mportant factor in gastric motility. However, the effect of hyperglyce
mia on gastric myoelectrical activity has not yet been studied in pati
ents with diabetes. Methods: Surface electrogastrography was performed
in eight patients with type I diabetes mellitus under normoglycemic a
nd hyperglycemic conditions (glucose clamp technique) and in eight nor
moglycemic control subjects. Results: In the early postprandial state,
the frequency of the normal pacemaker rhythm tended to be higher duri
ng hyperglycemia than during normoglycemia (3.10 +/- 0.27 vs. 2.92 +/-
0.19 cycle/min; P = 0.061). The frequency decrease that occurs immedi
ately after a meal was found less frequently during hyperglycemia (in
25% vs. 75% of the patients; P = 0.046). Higher harmonics of the 3 cyc
le/min component, indicating an electrogastrographic waveform change,
were found less often during hyperglycemia (in 13% vs. 63% of the pati
ents; P = 0.039). Dysrhythmias (in particular, tachygastriaa) were mor
e prevalent during hyperglycemia (40.6% vs. 6.5% of the time; P = 0.02
8). No differences were found between normoglycemic patients and contr
ol subjects. Conclusions: This study has shown that hyperglycemia is a
n important factor in the generation of gastric myoelectrical disturba
nces and tachygastrias in particular.