SPONTANEOUS OVULATORY CYCLE DONOR INSEMINATION PROGRAM - PROGNOSTIC INDICATORS OF A SUCCESSFUL PREGNANCY

The effects of female and male infertility factors as well as the inse mination regime on the outcome of donor insemination (DI) during 1001 spontaneous ovulatory cycles were assessed. Overall, the average month ly fecundability was 4.4% and the cumulative conception rate after nin e cycles was 45%. Female DI recipients' age, nulligravidity or the pre sence of other infertility factors were associated with a significantl y lower pregnancy rate. DI recipients of azoospermic partners had a si gnificantly higher pregnancy rate. The likelihood of a successful preg nancy was higher when more frequent (greater than or equal to 1) insem inations were used or in association with higher cervical score and la rger follicle diameter at the time of insemination. We suggest that fe male recipients of DI should be fully investigated before commencing D I treatment. Early resort to other methods of assisted reproduction sh ould be considered in DI recipients aged greater than or equal to 35 y ears, or in younger women if they fail to conceive after nine cycles o f DI. More frequent and better timing of inseminations is expected to improve the fecundability rate during spontaneous ovulatory DI cycles.