REGIOSPECIFIC ENZYMATIC HYDROXYLATIONS OF PYRAZINECARBOXYLIC ACID ANDA PRACTICAL SYNTHESIS OF 5-CHLOROPYRAZINE-2-CARBOXYLIC ACID

Authors
KIENER A RODUIT JP TSCHECH A TINSCHERT A HEINZMANN K
Citation
A. Kiener et al., REGIOSPECIFIC ENZYMATIC HYDROXYLATIONS OF PYRAZINECARBOXYLIC ACID ANDA PRACTICAL SYNTHESIS OF 5-CHLOROPYRAZINE-2-CARBOXYLIC ACID, Synlett, (10), 1994, pp. 814-816
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
10
Year of publication
1994
Pages
814 - 816
Database
ISI
SICI code
0936-5214(1994):10<814:REHOPA>2.0.ZU;2-2
Abstract
Three different microorganisms capable of metabolizing pyridinecarboxy lic acids were used for the regiospecific hydroxylation of all three r ing carbon atoms of pyrazinecarboxylic acid to 3-hydroxy-, 5-hydroxy- or 6-hydroxypyrazine-2-carboxylic acid1. 5-Hydroxypyrazine-2-carboxyli c acid was used for the preparation of 5-substituted pyrazine-2-carbox ylic acids.