TRABECULECTOMY WITH MITOMYCIN-C IN GLAUCOMA ASSOCIATED WITH UVEITIS

Twenty-four trabeculectomies performed in 24 patients for control of u veitic galucoma were retrospectively evaluated to analyze the effect o f intraoperative application of mitomycin C (MMC) on the short-term ou tcome of trabeculectomy for glaucoma associated with uveitis. Success rates, postoperative levels of intraocular pressure (IOP), and complic ations were studied. After a mean follow up of 9.87 months (range, 3 t o 27 months), 18 eyes (75%) achieved an IOP of 21 mm Hg or less withou t antiglaucoma medications. The same IOP levels with one antiglaucoma medication was achieved in four eyes (16.6%). Statistical analysis dem onstrated a significant reduction in IOP postoperatively during the pe riod studied (P = .0001). Complications observed included exacerbation of the uveitis (12.5%), choroidal detachment (12.5%), hypotony (8.3%) , postoperative shallow anterior chamber (4.2%), wound leak (4.2%), hy phema (4.2%), and macular edema (4.2%). The results of this retrospect ive and uncontrolled study suggest that intraoperative application of MMC may be a good option for enhancement of short-term trabeculectomy success rates in cases of uveitic glaucoma.