M. Takaoka et al., A CASE OF INTRACYTOPLASMIC EDEMA OF FOLLICULAR EPITHELIAL-CELLS IN RAT-THYROID, Journal of veterinary medical science, 56(5), 1994, pp. 989-991
Hydropic change of follicular epithelial cells in the thyroid was obse
rved in a female Fischer 344 rat. Microscopically follicular epithelia
l cells were characterized by edematous swelling with weakly eosinophi
lic and homogeneous cytoplasm. The cytoplasm was negative for periodic
acid-Schiff reaction, and thyroxine- and thyroglobulin-immunohistoche
mical reactions. Electron-microscopically, a small amount of amorphous
substance was noted in remarkably dilated rough-surfaced endoplasmic
reticulum (r-ER), and slight regressive changes of cytoplasmic organel
la were also observed. These morphological changes may indicate that f
ocal intracytoplasmic edema was occurred in r-ER, and that the change
belonged to hydropic degeneration of the thyroid follicular cells in t
he thyroid.