FLUCTUATING ASYMMETRY IN THE MUS MUSCULUS HYBRID ZONE - A HETEROTIC EFFECT IN DISRUPTED CO-ADAPTED GENOMES

Developmental stability reflects the organism's ability to buffer mino r developmental accidents and is often estimated by measuring the fluc tuating asymmetry. Either implicitly or explicitly, numerous authors h ave assumed that developmental stability is correlated with overall fi tness. If this is the case, changes in morphological asymmetry across a hybrid zone could be used as a measure of the selection on hybrid ge nomes. Developmental stability in hybrid populations is theoretically related to the genetic distance between hybridizing taxa, and results from a balance between the stabilizing effect due to increased heteroz ygosity and the disruptive effect caused by breakdown of genomic co-ad aptation. Here we have compared the amount of fluctuating asymmetry ac ross a transect of the hybrid zone between the two European subspecies of the house mouse (Mus musculus domesticus and M. m. musculus) in De nmark. For the first time in any natural hybrid zone we found an incre ased developmental stability in the populations with mixed genomes. Mo reover, the apparently beneficial effect of hybridization on the devel opmental stability of the hybrid mice contrasts with the results of bo th genetic and parasitological studies which show that hybrid dysgenes is occurs in this zone. Our results suggest that the barrier to gene f low in the Mus musculus hybrid zone may result from the disruption of relatively few gene systems. They also lead us to reassess the relatio n between developmental stability expressed as fluctuating asymmetry, coadaptation and overall fitness.