G(M2) ACTIVATOR PROTEIN EXPRESSION IN MOUSE-TISSUES

Citation
T. Beccari et al., G(M2) ACTIVATOR PROTEIN EXPRESSION IN MOUSE-TISSUES, Biochemical and biophysical research communications, 204(2), 1994, pp. 741-745
Citations number
22
Categorie Soggetti
Biology,Biophysics
ISSN journal
0006291X
Volume
204
Issue
2
Year of publication
1994
Pages
741 - 745
Database
ISI
SICI code
0006-291X(1994)204:2<741:GAPEIM>2.0.ZU;2-Y
Abstract
The G(M2) activator protein is an essential cofactor of hexosaminidase A in the degradation of G(M2) ganglioside and it is responsible for t he variant AB of G(M2) gangliosidosis in man. In this study G(M2) acti vator protein and its mRNA were determined in different mouse tissues. It was found that this protein is expressed mostly in the spleen and testis followed by brain and kidney which represent the main source in man. It is also interesting that in mouse testis there is a higher ex pression of the a subunit of hexosaminidase, thus suggesting a relatio nship between or subunit and G(M2) activator protein. Furthermore the results indicate that the expression of G(M2) activator protein is reg ulated, at least in part, at the transcriptional level. (C) 1994 Acade mic Press, Inc.