HEPATIC-METABOLISM OF CHLORAL HYDRATE TO FREE RADICAL(S) AMD INDUCTION OF LIPID-PEROXIDATION

Authors
NI YC WONG TY KADLUBAR FF FU PP
Citation
Yc. Ni et al., HEPATIC-METABOLISM OF CHLORAL HYDRATE TO FREE RADICAL(S) AMD INDUCTION OF LIPID-PEROXIDATION, Biochemical and biophysical research communications, 204(2), 1994, pp. 937-943
Citations number
25
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
204
Issue
2
Year of publication
1994
Pages
937 - 943
Database
ISI
SICI code
0006-291X(1994)204:2<937:HOCHTF>2.0.ZU;2-0
Abstract
Metabolism of chloral hydrate by male B6C3F(1) mouse liver microsomes generates free radical intermediate(s) as evidenced by electron spin r esonance spectroscopic analysis. The subsequent induction of endogenou s lipid peroxidation was shown by analysis of the resulting products w ith high-pressure liquid chromatography. Chloral hydrate was found mut agenic in Salmonella typhimurium strain TA104. Both lipid peroxidation and mutagenicity were efficiently inhibited by free radical scavenger s, alpha-tocopherol and menadione. (C) 1994 Academic Press, Inc.