EFFICACY OF ESCALATING DOSES OF LIPOSOMAL AMPHOTERICIN-B (AMBISOME) AGAINST HEMATOGENOUS CANDIDA-LUSITANIAE AND CANDIDA-KRUSEI INFECTION INNEUTROPENIC MICE
Nc. Karyotakis et Ej. Anaissie, EFFICACY OF ESCALATING DOSES OF LIPOSOMAL AMPHOTERICIN-B (AMBISOME) AGAINST HEMATOGENOUS CANDIDA-LUSITANIAE AND CANDIDA-KRUSEI INFECTION INNEUTROPENIC MICE, Antimicrobial agents and chemotherapy, 38(11), 1994, pp. 2660-2662
Immunosuppressed CF1 mice were infected intravenously with two strains
of Candida krusei and four strains of Candida lusitaniae (two of whic
h were resistant to amphotericin B). Mice were treated with 1 or 2 mg
of amphotericin B desoxycholate per kg of body weight per day or escal
ating doses of liposomal amphotericin B (8 to 30 mg/kg/day) or were le
ft untreated, Higher doses of liposomal amphotericin B were as effecti
ve as standard dose of amphotericin B desoxycholate in prolonging surv
ival but were significantly more effective in reducing the fungal burd
en in the kidneys of animals infected with both C. krusei strains and
the C. lusitaniae strains that were susceptible to amphotericin B deso
xycholate. This advantage of liposomal amphotericin B therapy could no
t be demonstrated in mice infected with the C. lusitaniae strains that
were resistant to amphotericin B desoxycholate.