Objectives: Advances in dental instrumentation and materials have allo
wed for increasingly conservative preparations when treating teeth for
dental caries. Research has shown that some materials, properly used,
can restore teeth to their pre-prepared strength. At the present time
, the longevity of these materials is unknown, requiring clinicians to
remain committed to conservative methods of tooth preparation. The pu
rpose of this study is to compare the resistance to fracture of teeth
prepared with occlusal, mesio-occlusal-distal (MOD) and mesial/distal
slot preparations against unprepared control teeth. Methods: Thirty-tw
o non-carious, non-restored human maxillary premolar teeth were divide
d into three experimental groups and a control group with eight teeth
in each. After preparation, the teeth were loaded to fracture on an In
stron Universal Testing Machine, and the results were compared using a
n Analysis of Variance (ANOVA) followed by Tukey's Studentized Range T
est (P < 0.05). Fracture patterns were compared by chi-square analysis
at the 0.1 level of probability. Results: There was no significant di
fference in fracture resistance among the experimental groups, but all
were less resistant to fracture than the unprepared control group. Th
e MOD and occlusal groups demonstrated a tendency towards vertical fra
cture while the mesial-distal slot and unprepared groups tended to a m
ore limited fracture of a single cusp. Conclusion: Any preparation app
ears to decrease a tooth's resistance to fracture. Conservative prepar
ation design may affect fracture pattern and enhance options for subse
quent restoration. Published by Elsevier Science Ltd.