RELATIONSHIP BETWEEN P53 AND C-ERBB-2 OVEREXPRESSION IN TISSUE-SECTIONS AND CYST FLUID CELLS OF PATIENTS WITH OVARIAN-CANCER

The expression of p53 protein and overexpression of c-erbB-2 oncoprote in was examined immunohistochemically and compared on frozen tissue se ctions and cyst fluid cells in patients with epithelial malignant and benign ovarian neoplasms. p53 was detected in 52.6% of carcinomas and c-erbB-2 expression was identified in 47.3% of cases. The relationship between p53 and c-erbB-2 overexpression in tissue sections and detach ed cyst fluid cells was evident. Moreover, a significant association b etween the presence of p53 and overexpression of c-erbB-2 proteins in tumor tissue sections and loose cyst fluid cells in individual patient s was demonstrated. In tissue sections and loose cyst fluid cells of b enign ovarian tumors no overexpression of p53 and c-erbB-2 proteins wa s found.