THE INFLUENCE OF THROMBOLYTIC APSAC THERA PY ON THE COURSE OF ACUTE MYOCARDIAL-INFARCTION

To evaluate the influence of thrombolytic therapy (TT) on the course o f acute myocardial infarction (AMI), a comparative analysis of clinica l and pathological findings was conducted. The latter included post mo rtem examination of 35 myocardial samples from patients treated with a psac in the acute phase of the infarction. The analysis indicated the predominance of cases with unfavourable coronary heart disease, severe myocardial damage and severe AMI complications in the group of the de ceased patients. The following beneficial effects of TT were reported: relatively safe stromal and parenchymal myocardial components, earlie r regeneration of the connective tissue. Late TT had a negative effect on MI because more hemorrhagic infarctiosn occurred. The combination of TT and myocardial repair modulators is proposed.