TREATMENT OF CHRONIC SUPPURATIVE OTITIS-M EDIA WITH TOPICAL TAUROLIDIN

In this pilot study 2% taurolidin solution was used for irrigation of infected ears and instillation topically in 10 patients with severe pu rulent otitis media. The main purpose of the study was to find out whe ther the application of the taurolidin solution into the middle ear wo uld cause significant pain or not. A slight increase in local pain was found sporadically but was not reason for withdrawing the drug. Twelv e of 13 bacterial species isolated prior to treatment were eliminated during the trial, with the otorrhea of most patients stopping after ju st the first instillation. Audiometric evaluations during and 30 month s after therapy did not reveal any ototoxic side effects. Tinnitus was not experienced by any patient during therapy. Overall findings demon strated that local therapy with taurolidin for patients with severe pu rulent otitis media was very well tolerated and effective bacteriologi cally. There were also no therapy-related complications or ototoxic si de effects.