SERUM CAROTENOIDS AND CORONARY HEART-DISEASE - THE LIPID RESEARCH CLINICS CORONARY PRIMARY PREVENTION TRIAL AND FOLLOW-UP-STUDY

Citation
Dl. Morris et al., SERUM CAROTENOIDS AND CORONARY HEART-DISEASE - THE LIPID RESEARCH CLINICS CORONARY PRIMARY PREVENTION TRIAL AND FOLLOW-UP-STUDY, JAMA, the journal of the American Medical Association, 272(18), 1994, pp. 1439-1441
Citations number
29
Categorie Soggetti
Medicine, General & Internal
ISSN journal
00987484
Volume
272
Issue
18
Year of publication
1994
Pages
1439 - 1441
Database
ISI
SICI code
0098-7484(1994)272:18<1439:SCACH->2.0.ZU;2-8
Abstract
Objective.-To examine the relationship between total serum carotenoid levels and the risk of subsequent coronary heart disease (CHD) events. Design.--New analysis of a cohort from the Lipid Research Clinics Cor onary Primary Prevention Trial and Follow-up Study (LRC-CPPT). The LRC -CPPT was a multicenter placebo-controlled trial of cholestyramine res in and CHD with a follow-up period of 13 years. Serum carotenoids were measured at baseline. Participants.-The placebo group of the LRC-CPPT , which consisted of 1899 men aged 40 to 59 years with type II-a hyper lipidemia and without known preexisting CHD, cancer, or other major il lnesses. Main Outcome Measures.-Nonfatal myocardial infarctions and de aths attributable to CHD ascertained from hospital records, autopsy re ports, and death certificates and reviewed by a panel of cardiologists . Results.-After adjustment for known CHD risk factors including smoki ng, serum carotenoids were inversely related to CHD events. Men in the highest quartile of serum carotenoids had an adjusted relative risk ( RR) of 0.64 (95% confidence interval [CI], 0.44 to 0.92) compared with the lowest quartile. For men who never smoked, this RR was 0.28 (95% CI, 0.11 to 0.73). Conclusions.-The LRC-CPPT participants with higher serum carotenoid levels had a decreased risk of incident CHD. This fin ding was stronger among men who never smoked.