ACUTE CHANGE OF EXERCISED MUSCLE USING MAGNETIZATION-TRANSFER CONTRAST MR-IMAGING

We evaluated the acute changes in exercised muscle using magnetization transfer contrast (MTC) MR imaging with a short repetition time seque nce. Ten volunteers performed supine ankle dorsiflexion exercise. MTC gradient-recalled echo (GRE) images were obtained before and after exe rcise at 1.5 T. The effect of MTC was assessed by dividing the signal intensity on MTC GRE images by that on conventional GRE images (M(s)/M (0)). The signal intensity, M(s)/M(0) and cross-sectional area of exer cised muscle were all greater at 1-2 min after exercise than immediate ly after exercise. We propose that this additional increase in these p arameters after exercise was due to physiological reflow or hyperemia. Since the M(s)/M(0) showed a good correlation with free water content in exercised muscle, this ratio may provide a quantitative variable f or evaluating dynamic change of water-macromolecule interaction in ske letal muscle,