ALLOPURINOL DOSE IS IMPORTANT FOR ATTENUATION OF LIVER DYSFUNCTION AFTER NORMOTHERMIC ISCHEMIA - CORRELATION BETWEEN BILE-FLOW AND LIVER-ENZYMES IN CIRCULATION

We have investigated the effect of two doses of allopurinol (ALL) (100 and 50 mg/kg) administered i.v. on liver function after 1 h of normot hermic ischemia. ALL given in a concentration of 100 mg/kg significant ly improved bile output after 1 and 24 h of reperfusion. Hepatocyte in jury reflected by alanine aminotransferase (ALT) and lactic dehydrogen ase (LDH) in plasma was also significantly reduced at 24 h, but not at 1 h of reperfusion compared with controls. ALL administered at a conc entration of 50 mg/kg had some protective effect. Significant correlat ion between circulating liver enzymes and bile output at 24 h after re perfusion indicates an important pathophysiologic link between hepatoc yte function and injury in this time window.