IDIOPATHIC CAPILLARY LEAK SYNDROME - EVIDENCE OF CD8-POSITIVE LYMPHOCYTES SURROUNDING DAMAGED ENDOTHELIAL-CELLS

Citation
M. Cicardi et al., IDIOPATHIC CAPILLARY LEAK SYNDROME - EVIDENCE OF CD8-POSITIVE LYMPHOCYTES SURROUNDING DAMAGED ENDOTHELIAL-CELLS, Journal of allergy and clinical immunology, 99(3), 1997, pp. 417-419
Citations number
10
Categorie Soggetti
Immunology,Allergy
ISSN journal
00916749
Volume
99
Issue
3
Year of publication
1997
Pages
417 - 419
Database
ISI
SICI code
0091-6749(1997)99:3<417:ICLS-E>2.0.ZU;2-T
Abstract
Idiopathic capillary leak syndrome (ICLS) is a lethal disease characte rized by recurrent fluid extravasation leading to hypovolemic shock un derlaid by marked hemoconcentration (hematocrit as high as 80%).(1) On ly 30 patients with ICLS have been reported in the literature, and the pathogenesis remains unknown. Extravasation of intravascular fluid, w ith similar clinical symptoms, is also a well-known complication of sy stemic administration of recombinant (r)IL-2.(2) In this last conditio n, direct in vivo interaction between IL-2-activated cells (probably L AK cells) and endothelium results in cytotoxicity to endothelial cells .(3) We previously provided evidence that cytokines participate in the pathogenesis of ICLS by demonstrating the appearance of IL-2 receptor -positive cells during attacks in a patient with this disease.(4) Now we have studied the pathology of the same patient, who died during an attack, and have found that in the skin there were perivascular infilt rates of CD8 lymphocytes surrounding damaged endothelial cells, a pict ure similar to that of rIL2-dependent capillary leak syndrome (CLS).