A PARTLY PARAMETRIC ADDITIVE RISK MODEL

Citation
Iw. Mckeague et Pd. Sasieni, A PARTLY PARAMETRIC ADDITIVE RISK MODEL, Biometrika, 81(3), 1994, pp. 501-514
Citations number
25
Categorie Soggetti
Mathematical Methods, Biology & Medicine","Statistic & Probability
Journal title
ISSN journal
00063444
Volume
81
Issue
3
Year of publication
1994
Pages
501 - 514
Database
ISI
SICI code
0006-3444(1994)81:3<501:APPARM>2.0.ZU;2-Z
Abstract
Aalen's additive risk model allows the influence of each covariate to vary separately over time. Although allowing greater flexibility of te mporal structure than a Cox model, Aalen's model is more limited in th e number of covariates it can handle. We introduce a partly parametric version of Aalen's model in which the influence of only a few covaria tes varies nonparametrically over time, and that of the remaining cova riates is constant. Efficient procedures for fitting this new model ar e developed and studied. The approach is applied to data from the Medi cal Research Council's myelomatosis trials.