REDUCTIVE DESILANOLATION AS A ROUTE TO BENZONITRILES - AN APPLICATIONTO A CONCISE SYNTHESIS OF THE AROMATIC SECTOR OF CALICHEAMICIN

Authors
OLSON SH DANISHEFSKY SJ
Citation
Sh. Olson et Sj. Danishefsky, REDUCTIVE DESILANOLATION AS A ROUTE TO BENZONITRILES - AN APPLICATIONTO A CONCISE SYNTHESIS OF THE AROMATIC SECTOR OF CALICHEAMICIN, Tetrahedron letters, 35(43), 1994, pp. 7901-7904
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
43
Year of publication
1994
Pages
7901 - 7904
Database
ISI
SICI code
0040-4039(1994)35:43<7901:RDAART>2.0.ZU;2-Z
Abstract
The TMS-cyanohydrins of quinones undergo reductive desilanolation in t he presence of samarium iodide to form hydroxybenzonitriles. Benzoquin one 1 was converted to the hexasubstituted aromatic fragment of calich eamicin 4 by this method.