SYNTHESIS OF BOTH ENANTIOMERS OF DYNEMICIN A MODEL-COMPOUND - NEW REMOTE ASYMMETRIC INDUCTION IN ACETYLIDE ADDITION INTO QUINOLINE NUCLEUS AS KEY STEP

Authors
NISHIKAWA T YOSHIKAI M OBI K ISOBE M
Citation
T. Nishikawa et al., SYNTHESIS OF BOTH ENANTIOMERS OF DYNEMICIN A MODEL-COMPOUND - NEW REMOTE ASYMMETRIC INDUCTION IN ACETYLIDE ADDITION INTO QUINOLINE NUCLEUS AS KEY STEP, Tetrahedron letters, 35(43), 1994, pp. 7997-8000
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
43
Year of publication
1994
Pages
7997 - 8000
Database
ISI
SICI code
0040-4039(1994)35:43<7997:SOBEOD>2.0.ZU;2-6
Abstract
A new and highly selective 1,4-asymmetric induction in the addition of magnesium acetylide into quinoline nucleus was developed. By using th is reaction, both enantiomers of dynemicin A model compound were synth esized from chiral alcohol which was prepared by lipase catalyzed reso lution.