Finding answers to the many open questions concerning the mechanism an
d control of prokaryotic translation remains one of the central challe
nges of molecular biology. In fact, recent experimental data even forc
e us to reconsider aspects that were previously thought to be establis
hed fact. Here, we attempt a synthesis of new and not-so-new informati
on, which leads to a revised and testable working hypothesis for trans
lational initiation.