CONTINUOUS MONITORING OF DEPTH OF SEDATION BY EEG SPECTRAL-ANALYSIS IN PATIENTS REQUIRING MECHANICAL VENTILATION

Twenty-three patients undergoing intensive therapy had continuous EEG recording in an attempt to assess depth of sedation using spectral ana lysis. Median power frequency (MPF) and spectral edge frequency (SEF) were calculated and correlated with the clinical sedation score and bl ood concentration of sedative drug. Fifteen patients received isoflura ne and eight midazolam. There was no correlation between MPF or SEF an d sedation score or blood concentration of drug. These results suggest that no simple measure of the EEG is likely to correlate with depth o f sedation in critically ill patients.