DOLICHOL AND VITAMIN-A CONTENT IN RAT-LIVER ITO (PERISINUSOIDAL) CELLS

Dolichol has been determined in many tissues but to date no data are a vailable on liver Ito (fat storing) cells. in this note dolichol was d etermined in two subpopulations of liver Ito cells isolated from rats pretreated with vitamin A: Ito-1, vitamin A enriched and Ito-2, relati vely poor of vitamin A. Differences were observed in the behaviour of the two fractions after vitamin A pretreatment of rats. In fact, in It o-1 fraction dolichol increases with the increase of vitamin A, while in Ito-2 fraction it does not change significantly with the increase o f vitamin A. These results, while confirming the heterogeneity of fat storing cells, are discussed as to the possible role of dolichol and v itamin A metabolism.