O. Gunhan et al., GENERALIZED GINGIVAL ENLARGEMENT DUE TO ACCUMULATION OF AMYLOID-LIKE MATERIAL, Journal of oral pathology & medicine, 23(9), 1994, pp. 423-428
Hyaline or amyloid-like substances may be seen in several oral lesions
. Some of these originate from epithelial cells and some from connecti
ve tissue components. In this study, amyloid-like material causing gin
gival enlargement in three patients, with eyelid involvement in two, w
as examined using histochemistry, immunohistochemistry and electron mi
croscopy. These accumulations did not share the classical features of
amyloid such as green birefringence under polarized light after Congo
red staining. Our findings suggest that epithelial degeneration plays
an important role in the pathogenesis of these amyloid-like accumulati
ons. These substances may be the result of defective amyloidogenesis a
nd our cases may represent an oral counterpart of ligneous conjunctivi
tis or colloid milium of the skin.