T. Haarmeier et al., ATTENUATION OF A VOLTAGE-DEPENDENT SODIUM CURRENT BY GABA (IDENTIFIEDNEURONS, BUCCAL GANGLIA, HELIX-POMATIA), Brain research, 663(1), 1994, pp. 131-139
The action of systemically applied GABA on voltage-dependent currents
of the identified neurons B1-B4 in the buccal ganglia of Helix pomatia
were investigated by conventional voltage clamp techniques. In the B4
neuron, superfusion with sodium-free solution or addition of tetrodot
oxin to the bath medium abolished the voltage dependent inward current
. This voltage dependent sodium current was reduced with GABA applicat
ion. Muscimol exerted the same effect as GABA whereas administration o
f baclofen had no effect. Voltage-dependent sodium and calcium current
s of the neurons B1-B3 remained unchanged with GABA application. It is
concluded that GABA is capable of reducing voltage-dependent sodium c
urrents of distinct neuronal individuals via a GABA(A) receptor-like s
tructure.