EFFECTS OF LOW-DOSE TRH ON COGNITIVE DEFICITS IN THE ECT POSTICTAL STATE

Authors
KHAN A MIROLO MH CLAYPOOLE K BHANG J COX G HORITA A TUCKER G
Citation
A. Khan et al., EFFECTS OF LOW-DOSE TRH ON COGNITIVE DEFICITS IN THE ECT POSTICTAL STATE, The American journal of psychiatry, 151(11), 1994, pp. 1694-1696
Citations number
19
Categorie Soggetti
Psychiatry,Psychiatry
Journal title
The American journal of psychiatry → ACNP
ISSN journal
0002953X
Volume
151
Issue
11
Year of publication
1994
Pages
1694 - 1696
Database
ISI
SICI code
0002-953X(1994)151:11<1694:EOLTOC>2.0.ZU;2-N
Abstract
A low dose (0.5 mg) of thyrotropin-releasing hormone (TRH), a short-ac ting tripeptide with known analeptic properties, was administered to e ight depressed patients 5 minutes after ECT session 3 or 4 in a double -blind, placebo-controlled crossover design. After TRH infusion the pa tients displayed selectively better performance on a battery of neurop sychological tests than they did after placebo infusion. Further explo ration with pharmacological probes to mitigate ECT postictal cognitive deficits is warranted.