BUSPIRONE ANALOGS AS LIGANDS OF THE 5-HT1A RECEPTOR-II - CAPACITY FACTORS AS CHROMATOGRAPHIC PARAMETER OF LIPOPHILICITY EVALUATION IN A SERIES OF 5-HT1A AND 5-HT2A RECEPTOR LIGANDS

Authors
CHILMONCZYK Z KSYCINSKA H CYBULSKI J WOZNIAKOWSKASZELEJEWSKA A
Citation
Z. Chilmonczyk et al., BUSPIRONE ANALOGS AS LIGANDS OF THE 5-HT1A RECEPTOR-II - CAPACITY FACTORS AS CHROMATOGRAPHIC PARAMETER OF LIPOPHILICITY EVALUATION IN A SERIES OF 5-HT1A AND 5-HT2A RECEPTOR LIGANDS, Die Pharmazie, 51(12), 1996, pp. 924-927
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
51
Issue
12
Year of publication
1996
Pages
924 - 927
Database
ISI
SICI code
0031-7144(1996)51:12<924:BAALOT>2.0.ZU;2-N
Abstract
The lipophilicity of a series of buspirone related agents was studied by means of reversed-phase HPLC using an octadecylsilane stationary ph ase and a mixture of aqueous solution of sodium phosphate and methanol as a mobile phase. Comparison of the measured capacity factors with l og P values has shown very good correlations with regression correlati on coefficients in the range of 0.994-0.996.