APPLICATION OF HPLC-MS-COUPLING FOR PHOTO STABILITY TESTING

The coupling of liquid chromatography and mass spectrometry is a helpf ul tool for various fields in pharmaceutical analysis. Regarding the p hotostability testing of drug substances one major application is the structure elucidation of degradation products. It also provides new po ssibilities for the detection of non-UV-active substances. The choice of a suitable interface plays an important role in the LC-MS-analysis. An instrument with a Particle Beam Interface was tested for its perfo rmance. Best results were obtained for uncharged molecules with lower to medium molecular masses.