AN IMPROVED FLOW-INJECTION METHOD FOR THE ASSAY OF PHENOTHIAZINE NEUROLEPTICS IN PHARMACEUTICAL PREPARATIONS USING FE(III) IONS

Authors
KARPINSKA J KOJLO A GRUDNIEWSKA A PUZANOWSKATARASIEWICZ H
Citation
J. Karpinska et al., AN IMPROVED FLOW-INJECTION METHOD FOR THE ASSAY OF PHENOTHIAZINE NEUROLEPTICS IN PHARMACEUTICAL PREPARATIONS USING FE(III) IONS, Die Pharmazie, 51(12), 1996, pp. 950-954
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
51
Issue
12
Year of publication
1996
Pages
950 - 954
Database
ISI
SICI code
0031-7144(1996)51:12<950:AIFMFT>2.0.ZU;2-X
Abstract
The flow injection method, involving spectrophotometric detection, is proposed for the determination of promazine hydrochloride and thiorida zine hydrochloride. The method is based on the oxidation of phenothiaz ines by iron(III) chloride in hydrochloric acid medium. Linear calibra tion graphs were obtained in the range 10-130 ppm and 10-210 ppm for b oth promazine and thioridazine with sampling rates of 136-148 samples/ h. The presented method was applied to the determination of promazine and thioridazine in pharmaceuticals.