It has been formulated and solved a mathematical model for the analysi
s and simulation of fluid bed reactors with locked enzymes in spherica
l porous particles. The model includes the influence of internal and e
xternal diffusional limitations, as well as the probable reversibility
of the enzymatic reaction. As a result of the simulation, the influen
ce on the conversion of different design parameters is obtained. This
model has been experimentally proved with the ONPG/ beta-galactosidase
system locked in Chromosorb-W.